8th Advances Against Aspergillosis
Lisboa Congress Centre, Lisbon, Portugal
1 – 3 February 2018
8th Advances Against Aspergillosis
Lisboa Congress Centre, Lisbon, Portugal
1 – 3 February 2018
8th Advances Against Aspergillosis
Lisboa Congress Centre, Lisbon, Portugal
1 – 3 February 2018
Programme
Go directly to a day’s programme
Thursday | Friday | Saturday
Thursday 1 February 2018 – Day 1 |
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|---|---|
Meet the Professor |
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| 08:00 – 08:50 | Aspergillus immunology and inflammation Teresa Zelante, PhD |
| 08:00 – 08:50 | Challenging cases in fungal asthma Ritesh Agarwal, MD DM |
| 09:00 – 09:15 | Introduction and summary of global disease burden David W. Denning, MBBS |
Optimizing Anti-Aspergillus TherapyModerators: William J. Steinbach, MD & Martin Höngl, MD |
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| 09:20 – 09:45 | Can we reduce fungal empiricism? Dimitrios P. Kontoyiannis, MD |
| 09:45 – 10:00 | Abstract #9: The investigational echinocandin CD101 demonstrates potent in vitro activity against Aspergillus fumigatus, including azole-resistant isolates Nathan P. Wiederhold, PharmD |
| 10:00 – 10:15 | Abstract #27: Early detection by pyrosequence profiling reveals triazole resistance in chronic pulmonary aspergillosis and allergic bronchopulmonary aspergillosis patient in the UK Malcolm Richardson, PhD |
| 10:15 – 10:30 | Abstract #165: Expression profile of clinical Aspergillus fumigatus isolates upon exposure to itraconazole Margriet Hokken, MSc |
| 10:30 – 10:55 | Managing breakthrough invasive aspergillosis Livio Pagano, MD |
10:55 – 11:25 | Coffee Break |
Drivers of the Immune ResponseModerators: Malcolm Richardson, PhD & Ashraf Ibrahim, PhD |
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| 11:25 – 11:50 | Why are NK cells important for defense against Aspergillus? Thomas Lehrnbecher, MD |
| 11:50 – 12:05 | Abstract #133: Airway tissue iron induces macrophage activation and Aspergillus fumigatus invasion in murine tracheal transplantation Efthymia Iliana Matthaiou, PhD |
| 12:05 – 12:20 | Abstract #93: IL-10 overexpression in vivo promotes susceptibility to aspergillosis by suppressing innate and adaptive pulmonary antifungal immunity Cláudio Duarte-Oliveira, MSc |
| 12:20 – 12:35 | Abstract #85: Neuraminidase-mediated sialic acid modification affects immune recognition of A. fumigatus Intan Dewi, MD |
| 12:35 – 13:00 | Fungus-specific T helper cells as potential diagnostic sensors for fungal infection and sensitization Alexander Scheffold, PhD |
| 13.00 – 13.10 | NIH Aspergillus & Zygomycete update Dona Love, PhD |
13.10 – 14.30 | Lunch and Poster Session 1 |
Therapy for the Next DecadeModerators: Olivier Lortholary, MD PhD & Manuel Abecassis, MD PhD |
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| 14:30 – 14:55 | Tissue penetration of antifungals Yanan Zhao, PhD |
| 14:55 – 15:10 | Abstract #149: Combination therapy with SCY-078 and isavuconazole for treatment of experimental invasive pulmonary aspergillosis in persistently neutropenic rabbit Vidmantas Petraitis, MD |
| 15:10 – 15:25 | Abstract #145: Discovery of a novel polyaminocarboxylate compound able to successfully treat invasive pulmonary aspergillosis in a murine model by interfering with fungal zinc metabolism Oumaima Ibrahim-Granet, PhD |
| 15:25 – 15:50 | Broad spectrum triazoles: which drug and when? Martin Hönigl, MD |
15:50 – 16:20 | Coffee Break |
Aspergillus: Entering the Host and BeyondModerators: David A. Stevens, MD & Fillipe Froes, MD |
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| 16:20 – 16:45 | Intermicrobial interactions with Aspergillus for survival in the airway Gabriele Sass, PhD |
| 16:45 – 17:00 | Abstract #127: Fungal conidia are efficiently sensed by immune cells in a perfused in vitro 3D- respiratory model Parul Chandorkar, MSc |
| 17:00 – 17:15 | Abstract #45: Insight into the surface proteome of A. fumigatus through comparative analysis with multiple allergy-inducing fungi Matthew Blango, PhD |
| 17.15 – 17.30 | Abstract #100: Clinical diagnostic criteria for allergic bronchopulmonary mycosis Koichiro Asano, MD |
| 17.30 – 17.55 | Recent advances in diagnosis and treatment of allergic aspergillosis Richard B. Moss, MD |
18.00 – 19.00 | Welcome Reception |
An Evening with the FDA and PMDAModerator: David W. Denning, MBBS |
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| 19.00 – 20.30 | Addressing clinical development questions for invasive, chronic and allergic aspergillosis Sumathi Nambiar, MD MPH FDA Junko Sato, PhD (written answers only) PMDA Admission by pre-booked ticket only. Limited places available. |
Go directly to a day’s programme
Thursday | Friday | Saturday
Friday 2 February 2018 – Day 2 |
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|---|---|
Meet the Professor |
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| 08:00 – 08:50 | Genetics of aspergillosis Agostinho Carvalho, PhD & Paul Bowyer, PhD |
| 08:00 – 08:50 | How to make a fast diagnosis Cornelia Lass-Flörl, MD PhD |
Airways and DiseaseModerators: Richard B. Moss, MD & Livio Pagano, MD |
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| 09:00 – 09:25 | How human factors regulate Aspergillus colonization in fungal allergy Sara Gago, PhD |
| 09:25 – 09:40 | Abstract #89: Potency of the airway epithelium against Aspergillus fumigatus in health and disease: a single cell quantitative approach Margherita Bertuzzi, PhD |
| 09:40 – 09:55 | Abstract #109: Detection of invasive pulmonary aspergillosis using lung perfusion SPECT with 99mTc-MAA in mice Masato Tashiro, MD PhD |
| 09:55 – 10:10 | Abstract #116: Evaluation of the role of TREM1 in invasive pulmonary aspergillosis Laura Alcazar-Fuoli, PhD |
| 10:10 – 10:35 | Why and when aspergillosis first appears in cystic fibrosis patients? Adilia Warris, MD PhD |
10:35 – 11:00 | Coffee Break |
Challenges for the Diagnostic LabModerators: Cornelia Lass-Flörl, MD PhD & Raquel Sabino, PhD |
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| 11:00 – 11:25 | Why are so many cases of invasive aspergillosis missed? Olivier Lortholary, MD PhD |
| 11:25 – 11:40 | Abstract #108: From mass spectrometry imaging to non-invasive diagnosis of aspergillosis: iron, ferricrocin and triacetylfusarinine C in rat lung tissue, serum and urine Vladimir Havlicek, PhD |
| 11.40 – 12.05 | Is phenotypic identification only to species complex acceptable? Ana Aalstruey-Izquierdo, PhD |
Pfizer Satellite SymposiumModerator: Andreas H. Groll, MD |
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New patient management opportunities in the fight against invasive mould disease (IMD) |
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| 12.05 - 12.10 | Welcome and overview of new treatment opportunities in high-risk patients Andreas H. Groll, MD |
| 12.10 - 12.30 | Current state of clinical practice and evolving challenges in the management of IMD Isabel Ruiz-Camps, MD PhD |
| 12.30 - 12.55 | Options and evidence for using targeted treatment and opportunities for tailored patient management with isavuconazole Andreas H. Groll, MD |
| 12.55 - 13.05 | Q&A session |
13.05 – 14.00 | Lunch |
| 14.00 -15.30 | Poster Viewing |
| 15.30 | Close |
Go directly to a day’s programme
Thursday | Friday | Saturday
Saturday 3 February 2018 – Day 3 |
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|---|---|
Meet the Professor |
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| 08:00 – 08:50 | News from the Chronic Aspergillosis Group Helmut Salzer, MD |
| 08:00 – 08:50 | Dormancy and germination in Aspergillus Michelle Momany, PhD |
Resistance in AspergillusModerators: David S. Perlin, PhD & Ana Alastruey-Izquierdo, PhD |
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| 09:00 – 09:25 | Mechanisms of non-CYP51 azole resistance Ling Lu, PhD |
| 09:25 – 09:40 | Abstract #42: In-host microevolution of Aspergillus fumigatus: a phenotypic and genotypic analysis Eloise Ballard |
| 09:40 – 09:55 | Abstract #2: A novel azole importer (Imp1) in Aspergillus fumigatus Aiah Khateb, MSc |
| 09:55 – 10:10 | Abstract #156: Understanding the mechanistic basis of echinocandin resistance in Aspergillus fumigatus Shruthi Satish, PhD |
| 10:10 – 10:35 | Global epidemiology of azole resistance in Aspergillus Anuradha Chowdhary, MD PhD |
10:35 – 11:05 | Coffee Break |
Basic Science Discovery and MechanismModerators: Michelle Momany, PhD & Célia Pais, PhD |
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| 11:05 – 11:30 | NMR & EM of biofilm and extracellular matrix Lynette Cegelski, PhD |
| 11:30 – 11:45 | Abstract #172: Structure of Aspergillus fumigatus calcineurin-FK506-FKBP12 complex reveals critical FKBP12-binding residues distinct from human FKBP12 and the potential for development of non-immunosuppressive FK506 analogs as antifungal therapeutics Praveen Juvvadi, PhD |
| 11:45 – 12:00 | Abstract #152: Canonical versus noncanonical autophagy in the fight against Aspergillus fumigatus infection Vasilis Oikonomou, PhD |
| 12:00 – 12:15 | Abstract #22: Hsp90 controls caspofungin paradoxical effect of Aspergillus fumigatus via the mitochondrial respiratory chain Marion Aruanno |
| 12:15 – 12:40 | Viruses of fungi, with a focus on Aspergillus Wendy Laureijssen-van de Sande, PhD |
12:40 – 14:10 | Lunch and Poster Session 2 |
Mucormycosis UpdateModerators: John Perfect, MD & Anuradha Chowdhary, MD PhD |
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| 14:10 – 14:35 | Contrasts between mucormycosis and aspergillosis in leukemia Nikolai Klimko, MD PhD |
| 14:35 – 15:00 | The genera and species of the Mucorales: an update Kerstin Voigt, PhD |
| 15:00 – 15:15 | Abstract #103: PCR-based diagnosis of mucormycosis targeting mucorales specific genes Clara Baldin, PhD |
| 15:15 – 15:30 | Abstract #26: RNA interference-dependent epimutations as a mechanism of drug resistance in Mucor circinelloides Zanetta Chang |
| 15:30 – 15:55 | Mucormycosis axis of evil: iron update, invasion and toxin production Ashraf Ibrahim, PhD |
| Session sponsored by Gilead | |
15:55 – 16:25 | Coffee Break |
Risks for Aspergillus-Related DiseasesModerators: Nikolai Klimko, MD PhD & Miguel Borrego, MD |
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| 16:25 – 16:50 | Why does ibrutinib carry a risk of cerebal aspergillosis? Georgios Chamilos, MD |
| 16:50 – 17:05 | Abstract #59: Disease-stratified incidence, risk factors and outcomes of galactomannan positive invasive aspergillosis Toine Mercier, MD |
| 17:05 – 17:30 | Occupational exposures and diseases Raquel Sabino, PhD |
| 17:30 – 17:45 | Abstract #56: Self-assessment and symptom domains of St George’s Quality of Life questionnaire predicts clinical failure in chronic pulmonary aspergillosis Felix Bongomin, MD |
| 17:45 – 18:10 | The human lung and Aspergillus: you are what you breathe in? Malcolm Richardson, PhD |
18:10 – 18:15 | Closing |
18:25 | Snacks and Discussion about AAA 2020 |
