8th Advances Against Aspergillosis

Lisboa Congress Centre, Lisbon, Portugal

1 – 3 February 2018

8th Advances Against Aspergillosis

Lisboa Congress Centre, Lisbon, Portugal

1 – 3 February 2018

8th Advances Against Aspergillosis

Lisboa Congress Centre, Lisbon, Portugal

1 – 3 February 2018


Go directly to a day’s programme
Thursday | Friday | Saturday

Thursday 1 February 2018 – Day 1

Meet the Professor

08:00 – 08:50Aspergillus immunology and inflammation
Teresa Zelante, PhD
08:00 – 08:50Challenging cases in fungal asthma
Ritesh Agarwal, MD DM
09:00 – 09:15Introduction and summary of global disease burden
David W. Denning, MBBS

Optimizing Anti-Aspergillus Therapy

Moderators: William J. Steinbach, MD & Martin Höngl, MD
09:20 – 09:45Can we reduce fungal empiricism?
Dimitrios P. Kontoyiannis, MD
09:45 – 10:00Abstract #9: The investigational echinocandin CD101 demonstrates potent in vitro activity against Aspergillus fumigatus, including azole-resistant isolates
Nathan P. Wiederhold, PharmD
10:00 – 10:15Abstract #27: Early detection by pyrosequence profiling reveals triazole resistance in chronic pulmonary aspergillosis and allergic bronchopulmonary aspergillosis patient in the UK
Malcolm Richardson, PhD
10:15 – 10:30Abstract #165: Expression profile of clinical Aspergillus fumigatus isolates upon exposure to itraconazole
Margriet Hokken, MSc
10:30 – 10:55Managing breakthrough invasive aspergillosis
Livio Pagano, MD
10:55 – 11:25
Coffee Break

Drivers of the Immune Response

Moderators: Malcolm Richardson, PhD & Ashraf Ibrahim, PhD
11:25 – 11:50Why are NK cells important for defense against Aspergillus?
Thomas Lehrnbecher, MD
11:50 – 12:05Abstract #133: Airway tissue iron induces macrophage activation and Aspergillus fumigatus invasion in murine tracheal transplantation
Efthymia Iliana Matthaiou, PhD
12:05 – 12:20Abstract #93: IL-10 overexpression in vivo promotes susceptibility to aspergillosis by suppressing innate and adaptive pulmonary antifungal immunity
Cláudio Duarte-Oliveira, MSc
12:20 – 12:35Abstract #85: Neuraminidase-mediated sialic acid modification affects immune recognition of A. fumigatus
Intan Dewi, MD
12:35 – 13:00Fungus-specific T helper cells as potential diagnostic sensors for fungal infection and sensitization
Alexander Scheffold, PhD
13.00 – 13.10NIH Aspergillus & Zygomycete update
Dona Love, PhD
13.10 – 14.30
Lunch and Poster Session 1

Therapy for the Next Decade

Moderators: Olivier Lortholary, MD PhD & Manuel Abecassis, MD PhD
14:30 – 14:55Tissue penetration of antifungals
Yanan Zhao, PhD
14:55 – 15:10Abstract #149: Combination therapy with SCY-078 and isavuconazole for treatment of experimental invasive pulmonary aspergillosis in persistently neutropenic rabbit
Vidmantas Petraitis, MD
15:10 – 15:25Abstract #145: Discovery of a novel polyaminocarboxylate compound able to successfully treat invasive pulmonary aspergillosis in a murine model by interfering with fungal zinc metabolism
Oumaima Ibrahim-Granet, PhD
15:25 – 15:50Broad spectrum triazoles: which drug and when?
Martin Hönigl, MD
15:50 – 16:20
Coffee Break

Aspergillus: Entering the Host and Beyond

Moderators: David A. Stevens, MD & Fillipe Froes, MD
16:20 – 16:45Intermicrobial interactions with Aspergillus for survival in the airway
Gabriele Sass, PhD
16:45 – 17:00Abstract #127: Fungal conidia are efficiently sensed by immune cells in a perfused in vitro 3D- respiratory model
Parul Chandorkar, MSc
17:00 – 17:15Abstract #45: Insight into the surface proteome of A. fumigatus through comparative analysis with multiple allergy-inducing fungi
Matthew Blango, PhD
17.15 – 17.30Abstract #100: Clinical diagnostic criteria for allergic bronchopulmonary mycosis
Koichiro Asano, MD
17.30 – 17.55Recent advances in diagnosis and treatment of allergic aspergillosis
Richard B. Moss, MD
18.00 – 19.00
Welcome Reception

An Evening with the FDA and PMDA

Moderator: David W. Denning, MBBS
19.00 – 20.30Addressing clinical development questions for invasive, chronic and allergic aspergillosis
Sumathi Nambiar, MD MPH

Junko Sato, PhD (written answers only)

Admission by pre-booked ticket only. Limited places available.

Go directly to a day’s programme
Thursday | Friday | Saturday

Friday 2 February 2018 – Day 2

Meet the Professor

08:00 – 08:50Genetics of aspergillosis
Agostinho Carvalho, PhD & Paul Bowyer, PhD
08:00 – 08:50How to make a fast diagnosis
Cornelia Lass-Flörl, MD PhD

Airways and Disease

Moderators: Richard B. Moss, MD & Livio Pagano, MD
09:00 – 09:25How human factors regulate Aspergillus colonization in fungal allergy
Sara Gago, PhD
09:25 – 09:40Abstract #89: Potency of the airway epithelium against Aspergillus fumigatus in health and disease: a single cell quantitative approach
Margherita Bertuzzi, PhD
09:40 – 09:55Abstract #109: Detection of invasive pulmonary aspergillosis using lung perfusion SPECT with 99mTc-MAA in mice
Masato Tashiro, MD PhD
09:55 – 10:10Abstract #116: Evaluation of the role of TREM1 in invasive pulmonary aspergillosis
Laura Alcazar-Fuoli, PhD
10:10 – 10:35Why and when aspergillosis first appears in cystic fibrosis patients?
Adilia Warris, MD PhD
10:35 – 11:00
Coffee Break

Challenges for the Diagnostic Lab

Moderators: Cornelia Lass-Flörl, MD PhD & Raquel Sabino, PhD
11:00 – 11:25Why are so many cases of invasive aspergillosis missed?
Olivier Lortholary, MD PhD
11:25 – 11:40Abstract #108: From mass spectrometry imaging to non-invasive diagnosis of aspergillosis: iron, ferricrocin and triacetylfusarinine C in rat lung tissue, serum and urine
Vladimir Havlicek, PhD
11.40 – 12.05Is phenotypic identification only to species complex acceptable?
Ana Aalstruey-Izquierdo, PhD

Pfizer Satellite Symposium

Moderator: Andreas H. Groll, MD

New patient management opportunities in the fight against invasive mould disease (IMD)

12.05 - 12.10Welcome and overview of new treatment opportunities in high-risk patients
Andreas H. Groll, MD
12.10 - 12.30Current state of clinical practice and evolving challenges in the management of IMD
Isabel Ruiz-Camps, MD PhD
12.30 - 12.55Options and evidence for using targeted treatment and opportunities for tailored patient management with isavuconazole
Andreas H. Groll, MD
12.55 - 13.05Q&A session
13.05 – 14.00

14.00 -15.30Poster Viewing

Go directly to a day’s programme
Thursday | Friday | Saturday

Saturday 3 February 2018 – Day 3

Meet the Professor

08:00 – 08:50News from the Chronic Aspergillosis Group
Helmut Salzer, MD
08:00 – 08:50Dormancy and germination in Aspergillus
Michelle Momany, PhD

Resistance in Aspergillus

Moderators: David S. Perlin, PhD & Ana Alastruey-Izquierdo, PhD
09:00 – 09:25Mechanisms of non-CYP51 azole resistance
Ling Lu, PhD
09:25 – 09:40Abstract #42: In-host microevolution of Aspergillus fumigatus: a phenotypic and genotypic analysis
Eloise Ballard
09:40 – 09:55Abstract #2: A novel azole importer (Imp1) in Aspergillus fumigatus
Aiah Khateb, MSc
09:55 – 10:10Abstract #156: Understanding the mechanistic basis of echinocandin resistance in Aspergillus fumigatus
Shruthi Satish, PhD
10:10 – 10:35Global epidemiology of azole resistance in Aspergillus
Anuradha Chowdhary, MD PhD
10:35 – 11:05
Coffee Break

Basic Science Discovery and Mechanism

Moderators: Michelle Momany, PhD & Célia Pais, PhD
11:05 – 11:30NMR & EM of biofilm and extracellular matrix
Lynette Cegelski, PhD
11:30 – 11:45Abstract #172: Structure of Aspergillus fumigatus calcineurin-FK506-FKBP12 complex reveals critical FKBP12-binding residues distinct from human FKBP12 and the potential for development of non-immunosuppressive FK506 analogs as antifungal therapeutics
Praveen Juvvadi, PhD
11:45 – 12:00Abstract #152: Canonical versus noncanonical autophagy in the fight against Aspergillus fumigatus infection
Vasilis Oikonomou, PhD
12:00 – 12:15Abstract #22: Hsp90 controls caspofungin paradoxical effect of Aspergillus fumigatus via the mitochondrial respiratory chain
Marion Aruanno
12:15 – 12:40Viruses of fungi, with a focus on Aspergillus
Wendy Laureijssen-van de Sande, PhD
12:40 – 14:10
Lunch and Poster Session 2

Mucormycosis Update

Moderators: John Perfect, MD & Anuradha Chowdhary, MD PhD
14:10 – 14:35Contrasts between mucormycosis and aspergillosis in leukemia
Nikolai Klimko, MD PhD
14:35 – 15:00The genera and species of the Mucorales: an update
Kerstin Voigt, PhD
15:00 – 15:15Abstract #103: PCR-based diagnosis of mucormycosis targeting mucorales specific genes
Clara Baldin, PhD
15:15 – 15:30Abstract #26: RNA interference-dependent epimutations as a mechanism of drug resistance in Mucor circinelloides
Zanetta Chang
15:30 – 15:55Mucormycosis axis of evil: iron update, invasion and toxin production
Ashraf Ibrahim, PhD
Session sponsored by Gilead
15:55 – 16:25
Coffee Break

Risks for Aspergillus-Related Diseases

Moderators: Nikolai Klimko, MD PhD & Miguel Borrego, MD
16:25 – 16:50Why does ibrutinib carry a risk of cerebal aspergillosis?
Georgios Chamilos, MD
16:50 – 17:05Abstract #59: Disease-stratified incidence, risk factors and outcomes of galactomannan positive invasive aspergillosis
Toine Mercier, MD
17:05 – 17:30Occupational exposures and diseases
Raquel Sabino, PhD
17:30 – 17:45Abstract #56: Self-assessment and symptom domains of St George’s Quality of Life questionnaire predicts clinical failure in chronic pulmonary aspergillosis
Felix Bongomin, MD
17:45 – 18:10The human lung and Aspergillus: you are what you breathe in?
Malcolm Richardson, PhD
18:10 – 18:15
Snacks and Discussion about AAA 2020